Web4 Dec 2013 · Here, we delineate the development of an automated HCS compatible imaging pipeline designed for live imaging of zebrafish kidneys in chemical screening scenarios. … WebThe changes of glutathione peroxidase (GSH-Px), reduced glutathione (GSH), total superoxide dismutase (T-SOD), catalase (POD), and malondialdehyde (MDA) in the zebrafish were detected by...
Validation, Optimization, and Application of the Zebrafish ...
Web1 Feb 2014 · The zebrafish is a popular model organism that is widely applied with lab-on-a-chip (LoC) technology in drug discovery and toxicity assay experiments. In such experiments, constant human... Web1 Sep 2024 · Zebrafish have almost 70% genetic homology with humans, and 82% of disease-causing human proteins are orthologue to zebrafish. The bottleneck in drug … export of france
Automated feature detection and imaging for high
Web1 hour ago · The most potent compound, acetochlor, was selected for further studies in zebrafish. Acetochlor exposure caused morphological malformations and lethality in zebrafish larvae with an EC50 of 7.8 uM and an LC50 of 12 uM. Acetochlor exposure also resulted in lipid accumulation is zebrafish larvae when simultaneously fed a high … Web1 Jan 2024 · Chemical screening in a zebrafish model of doxorubicin-induced cardiotoxicity identified the small molecules visnagin and diphenylurea, which rescued doxorubicin-induced cardiotoxicity in zebrafish and mice; visnagin bound to mitochondrial malate dehydrogenase (MDH2), and several MDH2 inhibitors exhibited similar cardioprotective … WebWe implemented a rapid workflow for automated imaging of medaka and zebrafish embryos and a new Heartbeat software for extraction of heart rate and rhythm. The multi-step pipeline is schematically summarized in Figure 1. The transparent chorion naturally constrains embryonic movement and therefore supersedes anesthesia or immobilization. export of fmcg products from india