Structural biology of bacterial iron uptake
WebJul 25, 2011 · @article{osti_1627465, title = {Structural and Sequence Analysis of Imelysin-Like Proteins Implicated in Bacterial Iron Uptake}, author = {Xu, Qingping and Rawlings, Neil D. and Farr, Carol L. and Chiu, Hsiu-Ju and Grant, Joanna C. and Jaroszewski, Lukasz and Klock, Heath E. and Knuth, Mark W. and Miller, Mitchell D. and Weekes, Dana and ... WebMaintaining iron homeostasis is fundamental for almost all living beings, and its deregulation correlates with severe and debilitating pathologies. The process is made more complicated by the omnipresence of iron and by its role as a fundamental component of a number of crucial metallo proteins. The response to modifications in the amount of the …
Structural biology of bacterial iron uptake
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WebJan 24, 2024 · • Hard working, adaptable, skilled scientific researcher with 12 years of experience, including 5 years of semi-independent research in premier US universities. • Proven record of accomplishments and communication skills in multiple fields with 15 peer-reviewed articles, 1 book chapter, 6 conference presentations and 2 patents. • Team … WebSep 1, 2007 · The iron sources are transported into the Gram-negative bacterial cell via specific uptake pathways which include an outer membrane receptor, a periplasmic …
WebFeb 6, 2024 · The bacteria were then grown for16–18 h at 16°C. The bacterial cells were harvested by centrifugation at 4000 rpm for 20 min at 16°C and resuspended in a lysis buffer (20 mM Tris, 150 mM NaCl, pH 9.0). The bacterial cells were lysed by sonication on ice. The cell debris was removed by centrifugation at 18 000 rpm for 40 min at 4°C. WebApr 1, 2003 · The bacterium then acquires the iron through the outer membrane receptor protein complex, which is an energy-dependent uptake process. But, not all bacteria use a …
WebNumerous bacterial proteins are involved in microbial iron uptake and transport and considerable variation has been found in the uptake schemes used by different bacterial … WebNumerous bacterial proteins are involved in microbial iron uptake and transport and considerable variation has been found in the uptake schemes used by dif...
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WebThe iron sources are transported into the Gram-negative bacterial cell via specific uptake pathways which include an outer membrane receptor, a periplasmic binding protein (PBP), … aline venutoWebThe iron sources are transported into the Gram-negative bacterial cell via specific uptake pathways which include an outer membrane receptor, a periplasmic binding protein … aline venantWebHaemophores are a class of secreted and cell surface-exposed proteins promoting free-haem uptake, haem extraction from host haem proteins, and haem presentation to specific outer-membrane receptors that internalize the metal-porphyrins. aline veraoWebApr 12, 2024 · Iron is an essential nutrient for bacteria but has poor bioavailability in the environment and in host organisms due to its sequestration and low solubility. To overcome this challenge, bacteria synthesize high-affinity iron-binding molecules called siderophores, which are recognized by specific transporters on the cell surface. aline vernatWebIn bacteria, Fe 2+ -dependent repressors bind to DNA upstream to genes involved in siderophore production at high intracellular iron concentrations. At low concentrations, Fe … aline verasWebMay 4, 2024 · Iron assimilation is commonly based on the production of siderophores, which are iron chelators produced to facilitate iron uptake. Siderophores are thus crucial for bacterial pathogenicity. Here we review the antimicrobial … aline vialetWebNov 11, 2012 · Whereas the uptake of iron compounds across the outer membrane of Gram-negative bacteria is facilitated by TonB-dependent receptors, active transport across the plasma membrane is catalyzed... aline vicari