Rnf4 and sumoylation
WebFeb 2, 2012 · RNF4 is an E3 ubiquitin ligase that preferentially targets sumoylated proteins. 13 Earlier studies have demonstrated that Tax can be both sumoylated and ubiquitylated, … WebMay 21, 2024 · Finally, our results together reveal a novel mechanism of protein stability control involving complex interplay between acetylation, de-acetylation, sumoylation, and …
Rnf4 and sumoylation
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WebOct 25, 2024 · A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways. Ubiquitin Chain Elongation Enzyme Ufd2 Regulates a Subset of Doa10 Substrates. Modification by Single Ubiquitin Moieties Rather Than Polyubiquitination Is Sufficient for … WebOct 13, 2010 · In acute promyelocytic leukemia (APL), the promyelocytic leukemia (PML) protein is fused to the retinoic acid receptor alpha (RAR). Arsenic is an effective treatment …
WebAbstract. Protein ubiquitylation and sumoylation play key roles in regulating cellular responses to DNA double-strand breaks (DSBs). Here, we show that human RNF4, a small … Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆
WebSep 18, 2012 · We have previously shown by BRET that PMLIII interacts with RNF4 in a SUMO-dependent manner since the SUMOylation deficient mutant, PMLIII-3KR, fails to … WebNov 27, 2024 · Here we report that the single SUMO E2 Ubc9 and the SUMO E3 ligases PIAS1, PIAS2, PIAS3, ZNF451, and NSMCE2 are direct RNF4 targets. We confirm PIAS1 as …
WebROS leads to increased ubiquitin carrier protein 9 (UBC9) binding to the PML RING domain, which increases PML-RARα SUMOylation and the recruitment of ring finger protein 4 …
WebMay 23, 2024 · Abstract: Protein ubiquitination and SUMOylation are important post translational modifications crucial for the maintenance of protein homeostasis and … spotify top songs 23 marchWebSep 22, 2024 · To validate that sumoylation at lysine 16 is necessary for the damage-induced interaction between RNF4 and Sp1, we used Sp1 −/− hTert-BJ1 cells and … shenandoah page county virginiaWebHowever, how SUMOylation influences protein ubiquitylation at DSBs is poorly understood. We show herein that Rnf4, an E3 ubiquitin ligase that targets SUMO-modified proteins, accumulates in DSB repair foci and is required for both homologous recombination (HR) and non-homologous end joining repair. spotify top podcasts listWebMar 9, 2024 · SLX4, disabled in Fanconi anemia group P, is a scaffolding protein that coordinates the action of structure-specific endonucleases and other proteins involved in … spotify top rated single pickup lineWebNov 1, 2024 · Free Online Library: BMN673 Is a PARP Inhibitor with Unique Radiosensitizing Properties: Mechanisms and Potential in Radiation Therapy. by "Cancers"; Health, general DNA damage Comparative analysis DNA repair Medical research Medicine, Experimental Olaparib Radiation (Physics) Radiotherapy Rucaparib spotify top songs by countryWebDescription: Homo sapiens histone cluster 1, H4k (H4C12), mRNA. RefSeq Summary (NM_003541): Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of … spotify top shared podcasts 20WebHowever, how SUMOylation influences protein ubiquitylation at DSBs is poorly understood. We show herein that Rnf4, an E3 ubiquitin ligase that targets SUMO-modified proteins, … shenandoah pa police department