Pttg1 transcription factor
WebJun 1, 2012 · Because ectopic expression of PTTG1 in normal breast MCF10A cells led to AKT activation, induction of transcription factor Snail, and acquisition of migratory and invasive properties, we next examined whether down-regulation of PTTG1 attenuates mesenchymal properties and thereby suppresses migration and invasiveness in breast … WebJun 29, 2024 · Pituitary tumor transforming gene-1 (PTTG1) transcription factor is identified as carcinogenic and associated with tumor invasiveness, but its role in bladder cancer …
Pttg1 transcription factor
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WebApr 1, 2007 · Transcription factors Sp1 and, to a lesser extent, nuclear factor-Y are important for basal transcription activity of the PTTG1 promoter (24, 42), particularly in cancer cells. The nuclear factor-Y site appears to be essential for DNA damage-induced and p53-mediated inhibition of PTTG1 transcription ( 42 ). WebNov 21, 2012 · Human pituitary tumor transforming gene-1 (PTTG1) is a novel oncogene. Its overexpression occurs in a wide variety of human tumors including pituitary adenomas. Several factors and signalling pathways regulate pituitary PTTG1 expression, including estrogen, epidermal growth factor, octamer-binding transcription factor 1 and Rb/E2F1.
WebAug 12, 2015 · PTTG1 interacts with transcription factors including p53, Sp1, and upstream stimulatory factor 1 (USF1), which may induce additional genes involved in tumorigenesis and cancer development [20, 23, 24]. In terms of colorectal cancer, PTTG1 overexpression is associated with tumourigenesis, progression and cancer metastasis . WebAug 16, 2013 · The aberrant expression of proto-oncogenes is involved in processes that are responsible for cellular proliferation and the inhibition of myeloid differentiation in acute …
WebNov 1, 2009 · Pituitary tumor-transforming gene-1 (PTTG1) is a transforming gene first discovered in rat pituitary tumor cells. It possesses transcriptional activity and also has … WebResults show that PTTG1 exhibits properties of a global transcription factor, and specifically modulates the G1/S-phase transition by interacting with Sp1. Data show that …
WebWe selected the lncRNA PTTG1-1:1, also identified as MIR3142HG or ENST00000517927, as the most upregulated lncRNA. ... SiRNA-mediated knockdown of p65/NF-kB further …
WebMar 12, 2007 · The results show that PTTG1 exhibits properties of a global transcription factor, and specifically modulates the G1/S-phase transition by interacting with Sp1. This … mayor of salfordWebJan 1, 2013 · Human pituitary tumor transforming gene 1 (PTTG1) is an oncogenic transcription factor that is overexpressed in many malignancies, especially cancers with metastatic potential, while transgelin-2 (TAGLN2) is an actin-binding protein shown to be a tumor suppressor. However, the expression and clinical significance of PTTG1 and … mayor of salem scWebChromatin immunoprecipitation-on-chip study reveals that PTTG1 is a global transcription factor, which exerts its transcriptional activity either by directly binding to DNA or by … mayor of saint paul minnesotaWebInterestingly, transcription factors were significantly underrepresented among the differentially expressed genes, and only one transcription factor, Pttg1, showed significant differences between ... mayor of salley scWebFeb 24, 2024 · Multivariate analyses confirmed that PTTG1 expression was a factor of prognosis that is independent in terms of LUAD patients. Besides, PTTG1 methylation had a negative regulation on PTTG1, so PTTG1 had a high expressing level in LUAD tissues. ... (PTTG1), a ubiquitously expressed factor of transcription, is proven with the … mayor of salem vamayor of saint petersburg flWebJan 28, 2015 · Background Pituitary tumor-transforming gene-1 (PTTG1) is a transcription factor that can affect transcriptional activity, angiogenesis, and cell senescence. We examined PTTG1 mRNA and protein expression in gastric cancer (GC) cell lines and tissues to determine its value as a biomarker for GC diagnosis and therapy. Methods PTTG1 … mayor of salt lake city political party