Progressive ankylosis protein homolog
WebAnkylosis protein (Ank), which transports intracellular inorganic pyrophosphate (PP (i)) to the extracellular milieu, is expressed by hypertrophic and, especially highly, by terminally differentiated mineralizing growth plate chondrocytes. WebThe progressive ankylosis protein (ANK) is a transmembrane protein that transports intracellular pyrophosphate (PPi) to the extracellular milieu. In this study we show …
Progressive ankylosis protein homolog
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WebProgressive ankylosis protein homolog; Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter; Belongs to the ANKH family (492 aa) ... Leucine-rich repeat and calponin homology domain-containing protein 1; Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine ... WebANKH is a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals.
WebDickkopf-related protein 1, an antagonist of Wnt/β-catenin signaling, has been reported to be either dysfunctional 88 or present at lower-than-normal levels in AS patients. 89 Serum levels of SOST are also lower in AS patients than healthy individuals. 90 Our recent work on ank/ank (progressive ankylosis) mice that have peripheral and spinal ... WebNov 16, 2001 · Protein Progressive ankylosis protein homolog Gene ANKH Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 492 Protein existence Evidence at protein level Annotation score 5/5 Entry Feature viewer … Publications - UniProt
WebThe ANKH protein plays a role in the development and function of cells that build bones (osteoblasts) and cells that break down bone (osteoclasts). Osteoclasts are involved in … WebAug 30, 2013 · It has been reported that subchondral bone explants from OA patients, secrete high levels of alkaline phosphatase (ALP), osteocalcin, osteopontin, IL-6, IL-8, and …
WebProgressive ankylosis protein homolog: Transmembrane: 327 – 347: Helical: Literature citations. Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia.
WebJun 26, 2014 · Progressive ankylosis protein homolog does, however, not substantially contribute to plasma PP i levels, which almost exclusively depend on ENPP1 activity and hence ATP release. 13 Based on the currently available data, we propose the model presented in Figure 3. Download figure; jcpenney nursing topsWebAlthough the etiology of apparent sporadic CPPD is not well-established, mutations in the ANK human gene (ANKH) have been shown to cause familial CPPD. In this Review, the key regulators of pyrophosphate metabolism and factors that lead to high extracellular pyrophosphate levels are described. jcpenney oakland mall phone numberWebProgressive ankylosis protein homolog: Topological domain: 1 – 85: Cytoplasmic: Alternative sequence: 1 – 198: Missing. In isoform 2. Literature citations. Mutations in the amino terminus of ANKH in two US families with calcium pyrophosphate dihydrate crystal deposition disease. lsi world cupWebprogressive ankylosis protein homolog 102808964 - Gene ResultLOC102808964 progressive ankylosis protein homolog [] Gene provides a unified query environment for … jcpenney ocoee flWebprogressive ankylosis protein homolog 104497836 - Gene ResultLOC104497836 progressive ankylosis protein homolog [] Gene provides a unified query environment for … jcpenney nursing gownsWebNov 1, 2024 · Further research into this topic revealed upregulation of other TGF-β isoforms and associated downstream targets such as connective tissue growth factor, while a deficiency of progressive ankylosis protein homolog gene/protein (ANKH)—recently demonstrated to transport ATP and citrate—was also found [[106, 107]]. The latter may … jcpenney oak court mallWebProgressive ankylosis protein homolog (ANK) Gene name : ANKH; Family name : ANKH Protein Recommended name Progressive ankylosis protein homolog Short: ANK Spliced into the following 2 isoforms jcpenney northwoods mall north charleston sc