Klf4 induction
WebApr 8, 2024 · In p53-mutated TNBC cells, inhibition of KLF4 by RNA interference reduced NOXA expression. Furthermore, treatment of TNBC cells with a KLF4-inducing small compound, APTO-253, resulted in the induction of NOXA expression and … WebMay 5, 2014 · A significant induction of KLF4 was observable within 2 hours of pitavastatin treatment, followed by THBD and NOS3 mRNA induction after 4 hours (Fig. S2A in File …
Klf4 induction
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WebKLF4 also known as gut-enriched Kruppel-like factor or epithelial zinc finger, is a 470 amino acid protein that is centrally distributed in epithelial cells of the gastrointestinal tract. ... The aberrant expression of Gli1, which can interact with HDAC1, leads to the induction of cancers [93], [135]. Furthermore, TGF-β has been found to ... WebKLF4 is essential for the cellular response to DNA damage. It is required for preventing cell cycle entry into mitosis following γ-irradiation-induced DNA damage, in promoting DNA repair mechanisms and in preventing the irradiated cell from undergoing programmed cell death (apoptosis).
WebIn ECs, KLF4 is a lineage-dependent transcription factor (TF) essential for endothelial lineage and a PS-induced signal-dependent TF . Under PS, KLF4 transcriptionally up-regulates … WebApr 18, 2024 · In murine esophageal epithelia, Klf4 overexpression causes chronic inflammation which is mediated by activation of NFκB signaling downstream of KLF4, and this esophageal inflammation produces epithelial hyperplasia and subsequent esophageal squamous cell cancer.
WebJun 2, 2009 · To identify a chemical replacement for Klf4, NL-MEFs were transduced with a subset of reprogramming factors comprising Oct4, Sox2, and c-Myc (OSM). To obtain the ≈10 9 cells needed to screen large chemical libraries required expansion of OSM-transduced NL-MEFs for 3 passages before screening.
WebMay 29, 2024 · Surprisingly, 308 of the 500 genes showed significantly elevated expression after KLF4 WT induction . For example, the expression of RHOC, RAC1, LMO7, and MIDN was up-regulated by induction of KLF4 WT but not R458A . This result suggested that mCpG-dependent KLF4-binding could activate cellular gene transcription and therefore, we …
WebMay 15, 2008 · Induction of Klf4 expression following vascular injury was abolished in conditional Klf4 -deficient mice. A, Experimental protocol showing the timing of 4-OHT injection, ligation injury, and harvesting tissues. park beach circle punta gorda flWebJun 2, 2009 · To identify a chemical replacement for Klf4, NL-MEFs were transduced with a subset of reprogramming factors comprising Oct4, Sox2, and c-Myc (OSM). To obtain the … park ave princess paletteWebAug 19, 2014 · Induction of KLF4 expression in ovarian cancer cells using lentiviral Tet-on vector. A. Lentiviral Tet-on vector system. Reverse transactivator (rtTA-M3) was driven by human ubiquitin C (UBC promoter), and EGFP or KLF4 was driven by the Dox inducible promoter TRE-tight. To induce the expression of EGFP or KLF4, Dox is required to activate … park avenue taglineWebJul 19, 2024 · KLF4 is a therapeutically tractable brake on fibroblast activation that promotes resolution of pulmonary fibrosis Go to The Journal of Clinical Investigation About Editors Consulting Editors For authors Publication ethics Transfers Advertising Job board Contact Current issue Past issues By specialty COVID-19 Cardiology Immunology … parkbusinesscap.comWebThere is evidence to suggest that transcription factor KLF4 plays a crucial role in the progression of breast carcinoma, 14 squamous cell carcinoma, 15 lung cancer, 16 and colon cancer. 13 Therefore, KLF4 is a potential diagnostic marker, prognostic factor, or target for novel therapy. To the authors’ knowledge, this is the first study to ... オムスビハットリWebJun 8, 2015 · The expression of KLF4 is positively regulated by ERK in tumor cells from several origins, 15, 26 and it is considered to be involved in monocytic differentiation of myeloid cells. 16 When we... おむすびママWebApr 10, 2024 · KLF4 contains an activation domain as well as a repression domain 21 and is therefore able to induce and suppress the transcription of different genes including molecules involved in the regulation of the immune response ( … おむすびと 鮭