Cyclophosphamide h9c2
WebThe H9c2 cells are a common model to study the cardiotoxicity of anticancer drugs [62][63][64]. ... The Main Metabolites of Fluorouracil + Adriamycin + Cyclophosphamide (FAC) Are Not Major... Webcombination (5-Fluorouracil + Adriamycin + Cyclophosphamide, FAC) in H9c2 cardiac cells, for a better understanding of the contribution of each drug to FAC-induced cardiotoxicity. Differentiated H9c2 cells were exposed to pharmacological relevant concentrations of DOX (0.13–5 μM), 5-FU (0.13–5 μM), CYA (0.13–5 μM) for 24 or 48 h.
Cyclophosphamide h9c2
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WebJun 26, 2015 · Cyclophosphamide (CY) is metabolized to 4-hydroxy-cyclophosphamide (HCY) in the hepatic cytochrome P-450 enzyme (CYP) system (CYP2B6 and/or … WebOct 1, 2024 · Thirty-eight patients with advanced breast cancer were treated with the 'VEMFAH' multiple-drug combination chemotherapy, consisting of vincristine (V), cyclophosphamide (Endoxan; E), methotrexate...
WebJun 26, 2015 · Abstract. Observed only after administration of high doses, cardiotoxicity is the dose-limiting effect of cyclophosphamide (CY). We investigated the poorly … WebNational Center for Biotechnology Information
WebMay 17, 2024 · Cyclophosphamide (CPA) and doxorubicin (DOX) are 2 key components among the most commonly used chemotherapy regimens for TNBC . Although this drug … WebOct 1, 2024 · Chemotherapy with cyclophosphamide (Cytoxan, Neosar), methotrexate, and fluorouracil (CMF) seems to be safe and effective in patients with breast cancer.
WebCyclophosphamide is in a class of medications called alkylating agents. When cyclophosphamide is used to treat cancer, it works by slowing or stopping the growth of …
WebJun 16, 2014 · The rat cardiocytes (H9c2) cell line and the human colon adenocarcinoma (HT-29) cell line obtained from the American Type Tissue Culture Collection, Rockville, … scotrail badgeCyclophosphamide (CY) is metabolized to 4-hydroxy-cyclophosphamide (HCY) in the hepatic cytochrome P-450 enzyme (CYP) system (CYP2B6 and/or CYP2C19). HCY enters cells as tautomer aldocyclophosphamide (AldoCY). Through β-elimination, AldoCY can be converted to phosphoramide mustard (PM) and … See more CY (Cat. #C0768), dimethyl sulfoxide (DMSO: Cat. #D2650), NAC (Cat. #A9165), and metaphosphoric acid (MPA: Cat. #239275) were purchased from SIGMA-Aldrich (St. Louis, MO), HCY (Cat. #sc-206885) and … See more H9c2 cell line embryonic rat cardiomyocytes (Cat. #CRL-1446) were supplied by the American Type Culture Collection (ATCC, Manassas, VA). The H9c2 specimens … See more To detect intracellular ROS, we used dichlorofluorescin diacetate (DCFH-DA) molecular probes (Cat. #D6883; SIGMA-Aldrich) as our previous study [11]. Briefly, H9c2 cells were … See more H9c2 cells were plated at 2.5 × 104 cells/mL density in 24-well plates and grown overnight. These samples were exposed to CY … See more premier protein chocolate hazelnut with oatsWebMar 11, 2024 · Seven-day differentiated H9c2 cells were exposed for 48 h to the main metabolites of FAC, namely the metabolite of 5-FU, α-fluoro-β-alanine (FBAL, 50 or 100 μM), of DOX, doxorubicinol (DOXOL, 0.2... premier protein chocolate hazelnut shakeWebCyclophosphamide itself did not have a toxic effect, whereas the toxicity of acrolein is 1, 000 times higher than that of doxorubicin in the H9c2 cell line. Acrolein, but not … premier protein 1 whey protein powder vanillaWebAbstract. The anticancer drug cyclophosphamide induces granulosa cell apoptosis and is detoxified by glutathione (GSH) conjugation. We previously showed that both … scotrail ayr to glasgowWebIn the clinical practice, the combination of 5-fluorouracil (5-FU) + Adriamycin (also known as doxorubicin, DOX) + cyclophosphamide (CYA) (known as FAC) is used to treat breast cancer. The FAC therapy, however, carries some serious risks, namely potential cardiotoxic effects, although the mechanisms are still unclear. scotrail balloch to glasgowWebDec 21, 2024 · Cyclophosphamide (Cyclo) is one of the oldest chemotherapies used to treat lung and breast cancer [ 22 ]. Moreover, it is applied to other types of cancer such as leukemia, lymph, bladder, and ovary [ 22 ]. scotrail back office