WebOct 26, 2024 · CMTM6 knockdown of OSCC cells inhibited proliferative, migrative and invasive abilities of OSCC cells, as well as inhibited M2 macrophage polarization in vitro with downregulating PD-L1 expression. ... CMTM6, a potential immunotherapy target. Liang J, Li S, Li W, Rao W, Xu S, Meng H, Zhu F, Zhai D, Cui M, Xu D, Cai J, Zhang B. J Cancer … WebOct 7, 2024 · CMTM6 has been mostly studied in the context of anti-tumor immunity by regulating plasma membrane expression of programmed death ligand-1 (PDL1/CD274) …
CMTM6 and PD-L1 coexpression is associated with an active …
WebAug 7, 2024 · Expression of CMTM6 was more frequent than expression of PD-L1, consistent with prior literature [18, 19], which indicates that CMTM6 could be regarded as a potential target for immunotherapy. Consistent with our results, upregulation of PD-L1 is observed during HBV infection [ 27 ]. WebAug 18, 2024 · Thus, CMTM6 was suggested to be a potential target of the immunotherapy for gliomas. Critically, a high level of CMTM6 was associated with a poor prognosis. ... These findings establish CMTM6 as … bpi philam life contact number
CMTM6, a potential immunotherapy target SpringerLink
WebMar 14, 2024 · Overall, this work conceptually highlighted the effect of the combination immunotherapy based on the oncolytic peptide and immune checkpoint blockade and further demonstrated the critical role of ATP11B in PD-L1 regulation. ... with a 27% 2-year overall survival.52 Although these results underline the therapeutic potential of CMTM6 … WebAug 24, 2024 · Ferroptosis is a new type of programmed cell death that plays a pivotal role in a variety of tumors. Moreover, immunity is closely related to ferroptosis. However, immune-ferroptosis-related mRNAs (IFRMs) are still not fully understood in the regulation of head and neck squamous cell carcinoma (HNSC). The purpose of this paper was to … WebAug 16, 2024 · Here we identify the uncharacterized protein CMTM6 as a critical regulator of PD-L1 in a broad range of cancer cells, by using a genome-wide CRISPR–Cas9 screen. CMTM6 is a ubiquitously expressed ... gyms lawrenceburg ky