In breast cancer research CD44+/CD24- expression is commonly used as a marker for breast CSCs and is used to sort breast cancer cells into a population enriched in cells with stem-like characteristics and has been seen as an indicator of increased survival time in epithelial ovarian cancer patients. See more The CD44 antigen is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration. In humans, the CD44 antigen is encoded by the CD44 gene on chromosome 11. CD44 has been … See more CD44 is expressed in a large number of mammalian cell types. The standard isoform, designated CD44s, comprising exons 1–5 … See more The protein is a determinant for the Indian blood group system. • CD44, along with CD25, is used to track early See more CD44 has been shown to interact with: • ARHGEF1, • Ezrin, via PIP2, • Epidermal Growth Factor Receptor (Hyaluronan-dependent), • Fibrin and immobilized fibrinogen, See more CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, … See more CD44 is a multistructural and multifunctional cell surface molecule involved in cell proliferation, cell differentiation, cell migration, angiogenesis, presentation of See more • Sackstein R (Jul 2011). "The biology of CD44 and HCELL in hematopoiesis: the 'step 2-bypass pathway' and other emerging perspectives". Current Opinion in Hematology. 18 (4): 239–48. doi:10.1097/MOH.0b013e3283476140. PMC 3145154 See more WebDec 10, 2024 · CD44 represents a common biomarker of cancer stem cells, and promotes epithelial-mesenchymal transition. CD44 is involved in the regulation of diverse vital signaling pathways that modulate cancer proliferation, invasion, metastasis and therapy-resistance, and it is also modulated by a variety of molecules in cancer cells.
CD44 - Wikipedia
WebDetection of CD24 and CD44 on paraffin section of organoids. Paraffin sections of BCO#140, #154, and #147 were generated and stained with primary antibodies reactive with bladder cancer stem-cell markers CD24 and CD44. Expression of CD24 was visualized by a green fluorescent AlexaFluor488-labelled detection antibody. s6201 cerfa
Clinical relevance of stem cell surface markers CD133, CD24, and …
WebOct 23, 2024 · CD44/CD24 and ALDH1 are widely used cancer stem cell (CSC) markers in breast cancer. However, their expression is not always consistent even in the same … WebJun 1, 2011 · CD44 + CD24 – cells highly express genes involved in invasion and angiogenesis and display activated TGF-β–, Hh-, and PLAU-signaling pathways, whereas markers and pathways of luminal epithelial differentiation are more abundant in CD44 – … WebAug 6, 2008 · Using this model, we demonstrate that CD44 + CD24 −/low cells possessing stem-like properties can be generated from CD44 low CD24 + non-tumorigenic mammary epithelial cells through activation of the Ras/MAPK signaling pathway and can be accelerated by EMT induction. Results s620101